%0 Journal Article
%T The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese
%A Yang Jiyun
%A Li Guisen
%A Zhu Li
%A Shi Yi
%A Lv Jicheng
%A Lu Fang
%A Liu Xiaoqi
%A Ma Shi
%A Jing Cheng
%A Lin Ying
%A Wang Haiyan
%A Wang Li
%A Zhang Hong
%A Yang Zhenglin
%J BMC Medical Genetics
%D 2012
%I BioMed Central
%R 10.1186/1471-2350-13-33
%X In this study, 192 patients with IgAN and 192 normal controls in the Sichuan cohort and 935 patients with IgAN and 2,103 normal controls in the Beijing cohort were investigated. HLA-DRB1*01¨CDRB1*10 specificities were genotyped by the PCR¨CSSP technique in both cohorts. Based on the HLA-DRB1*04-positive results, the subtypes of HLA-DRB1*04 were analyzed using sequencing-based typing (SBT) in 291 IgAN cases and 420 matched controls.The frequency of HLA-DRB1*04 in the IgAN group was significantly higher than that in the control group (0.129 vs. 0.092, P£¿=£¿8.29£¿¡Á£¿10-5, odds ratio (OR) =1.381, 95% confidence interval (CI) 1.178¨C1.619). Other alleles at the HLA-DRB1 locus were observed with no significant differences between the case and control groups. The dominant alleles of the HLA-DRB1*04 subtypes were DRB1*0405 in both cohorts. The frequencies of HLA-DRB1*0405 and 0403 were significantly increased in the patients compared to healthy subjects.HLA-DRB1*04 was significantly associated with primary IgAN in Chinese population. This result implies that HLA-DRB1 gene plays a major role in primary IgAN.
%K IgA nephropathy
%K HLA-DRB1
%K Association study
%U http://www.biomedcentral.com/1471-2350/13/33/abstract