%0 Journal Article
%T Circulating leukocyte telomere length is highly heritable among families of Arab descent
%A Omar Al-Attas
%A Nasser Al-Daghri
%A Majed Alokail
%A Khalid Alkharfy
%A Assim Alfadda
%A Philip McTernan
%A Greg Gibson
%A Shaun Sabico
%A George Chrousos
%J BMC Medical Genetics
%D 2012
%I BioMed Central
%R 10.1186/1471-2350-13-38
%X A total of 119 randomly selected Saudi families (123 adults and 131 children) were included in this cross-sectional study. Anthropometrics were obtained and fasting blood samples were taken for routine analyses of fasting glucose and lipid profile. Leukocyte telomere length was determined using quantitative real time PCR.Telomere length was highly heritable as assessed by a parent-offspring regression [h2£¿=£¿0.64 (p£¿=£¿0.0006)]. Telomere length was modestly associated with BMI (R2 0.07; p-value 0.0087), total cholesterol (R2 0.08; p-value 0.0033), and LDL-cholesterol (R2 0.15; p-value 3 x 10-5) after adjustments for gender, age and age within generation.The high heritability of telomere length in Arab families, and the associations of telomere length with various cardiometabolic parameters suggest heritable genetic fetal and/or epigenetic influences on the early predisposition of Arab children to age-related diseases and accelerated ageing.
%K Telomere length
%K Heritability
%K Arabs
%K Ageing
%U http://www.biomedcentral.com/1471-2350/13/38/abstract