%0 Journal Article
%T Are drugs necessary in obesity treatment?
%A Ivkovi£¿-Lazar Tatjana A.
%A Stoki£¿ Edita J.
%A Lep£¿anovi£¿ Lazar
%J Medicinski Pregled
%D 2002
%I Serbian Medical Society, Society of Physicians of Vojvodina, Novi Sad
%R 10.2298/mpns0202023i
%X The main principles of obesity treatment are dietetic nutrition, physical activity and psychotherapy. Drug therapy is adjuvant, time limited and can be applied only with the mentioned therapeutic measures. An ideal antiadipose agent induces a potent decrease of body mass on the account of fat depot, it can be administered for a prolonged time without developing resistance, it should not be accompanied by significant side effects, and it has no negative effects on the obesity-related diseases. Anti-obesity agents Nowadays, there are mainly two groups of drugs in use, having different mechanisms of action: appetite suppressors and fat resorption inhibitors. From the first group of drugs the most suitable is dexfenfluramine, which is applied in obese nervous and tense subjects and in cases of compulsive food intake whereas fat resorption inhibitors (tetrahydrolipstatin, orlistat) are especially recommended to obese patients with accompanying hyperlipoproteinemia. Insulin-dependent form of diabetes is an indication for administration of drugs from this group. Conclusion Of course, before applying drugs it is necessary to thoroughly consider indications and especially contraindications of their action. In respect to the treatment duration, three-month treatments are mainly recommended. Prolonged courses are acceptable only if well-controlled studies are in question.
%K Obesity + therapy + drug therapy
%K Anti-Obesity Agents + contraindications + therapeutic use
%K Appetite Depressants + contraindications + therapeutic use
%U http://www.doiserbia.nb.rs/img/doi/0025-8105/2002/0025-81050202023I.pdf