%0 Journal Article
%T Epidemiology and outcomes of community-onset methicillin-susceptible Staphylococcus aureus bacteraemia in a university hospital in Singapore
%A Jonathan Chia
%A Li-Yang Hsu
%A Louis Chai
%A Paul Tambyah
%J BMC Infectious Diseases
%D 2008
%I BioMed Central
%R 10.1186/1471-2334-8-14
%X A single-centre retrospective case series profiling all patients with community onset-MSSA bacteraemia presenting between March 2005 and February 2006 to a tertiary acute-care university hospital in Singapore. In addition to epidemiological and clinical data collection, risk factors for complicated bacteremia and attributable mortality were analysed.A total of 100 patients met the case definition. Patients were more likely to be male (65%) and below 65 years of age (69%). Seventeen patients were intravenous drug abusers, while 38 had diabetes mellitus. There were 18 cases of endocarditis, with 11 occurring in intravenous buprenorphine abusers. Attributable mortality was 11%, and 46% of patients developed complicated bacteremia. On multivariate analysis, age > 65 years and presence of chronic pulmonary disease were the only significant risk factors for the former, while valvular heart disease was a significant risk factor for the latter.MSSA bacteraemia is associated with a significant risk of serious complications in Singapore. Other Asian cities should be alert to the risk factors for adverse outcomes for this important cause of morbidity and mortality.Staphylococcus aureus bacteraemia remains a common cause of mortality and morbidity both in spite of and as a consequence of medical advances. Although the mortality rate has declined in some countries as a result of improved quality of care [1], the overall prevalence has increased in line with increasing use of intravascular devices and an expanding "at-risk" population [1,2].The focus in recent years has been on infections caused by methicillin-resistant S. aureus (MRSA), especially with regards to its clinical and economic impact in comparison with methicillin-susceptible S. aureus (MSSA) [3,4]. The rapid rise of infections caused by community-associated MRSA (CA-MRSA) has further directed attention towards MRSA [5,6]. Nevertheless, CA-MRSA is still relatively rare on a global basis, whereas MSSA is a more common
%U http://www.biomedcentral.com/1471-2334/8/14