%0 Journal Article
%T Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study
%A Ilias Porfyridis
%A Diamantis Plachouras
%A Vasiliki Karagianni
%A Anastasia Kotanidou
%A Spyridon A Papiris
%A Helen Giamarellou
%A Evangelos J Giamarellos-Bourboulis
%J BMC Infectious Diseases
%D 2010
%I BioMed Central
%R 10.1186/1471-2334-10-286
%X 68 patients admitted to a medical ward with acute respiratory illness were enrolled in the study. Neutrophil and monocyte TREM-1 expression were measured by flow cytometry, sTREM-1 by an enzyme immunoassay and C-reactive protein by nephelometry. Clinical pulmonary infection score was recorded.34 patients were diagnosed with bacterial community acquired pneumonia (group A) and 34 with non-bacterial pulmonary disease (group B). Median serum TREM-1 concentration was 102.09 pg/ml in group A and lower than 15.10 pg/ml (p < 0.0001) in group B. Mean¡ÀSE neutrophil TREM-1 expression was 4.67 ¡À 0.53 MFI in group A and 2.64 ¡À 0.25 MFI (p = 0.001) in group B. Monocyte TREM-1 expression was 4.2 ¡À 0.42 MFI in group A and 2.64 ¡À 0.35 MFI (p = 0.007) in group B and mean¡ÀSE CRP was 18.03 ¡À 2 mg/ml in group A and 7.1 ¡À 1.54 mg/ml (p < 0.001) in group B. A cut-off of 19.53 pg/ml of sTREM-1 with sensitivity 82.6% and specificity 63% to discriminate between infectious and non-infectious pulmonary infiltrates was found. sTREM-1 at admission greater than 180 pg/ml was accompanied with unfavourable outcome.TREM-1 myeloid expression and sTREM-1 are reliable markers of bacterial infection among patients with pulmonary infiltrates; sTREM-1 is a predictor of final outcome.Early diagnosis of lung infections remains a challenge. There is no gold standard for diagnosing microbial infection as clinical and laboratory signs are neither sensitive nor specific enough, and microbiological studies often remain negative. The presence of a new infiltrate on plain chest radiograph is considered indicative for diagnosing pneumonia, especially when is supported by clinical and laboratory findings. However it is difficult to differentiate a chest infiltrate of bacterial origin from a chest infiltrate of non-bacterial origin solely based on radiological criteria [1]. The diagnosis of infection is not always clear in the acute setting in patients with respiratory tract disease and a surrogate marker of infecti
%U http://www.biomedcentral.com/1471-2334/10/286