%0 Journal Article
%T Overwhelming postsplenectomy infection due to Mycoplasma pneumoniae in an asplenic cirrhotic patient: Case report
%A Feng Xu
%A Chao-Liu Dai
%A Xing-Mao Wu
%A Peng Chu
%J BMC Infectious Diseases
%D 2011
%I BioMed Central
%R 10.1186/1471-2334-11-162
%X We report a case of OPSI in a 41-year-old woman with hypersplenism associated with hepatitis B cirrhosis. We detected a significant Mycoplasma pneumoniae agglutination titer, but no evidence of infection with Chlamydia pneumoniae, Legionnella spp., or any other bacterial or fungal pathogens. She eventually died despite aggressive therapy.M. pneumoniae could be an underestimated cause of OPSI, and should be suspected in fulminant infectious cases in asplenic patients.Overwhelming postsplenectomy infection (OPSI) is a rare condition and extremely dangerous in asplenic individuals. The most common pathogen associated with OPSI is Streptococcus pneumoniae [1]. There have not been any published case reports on OPSI, in which Mycoplasma pneumoniae was implicated. We report here on an adult patient who had undergone splenectomy for hypersplenism associated with hepatitis B cirrhosis and eventually developed OPSI possibly caused by M. pneumoniae.On November 14, 2010, a 41-year-old woman was admitted to our hospital with complaints of high fever and chills of 10-hour duration. Three weeks prior she had undergone a splenectomy for pancytopenia associated with splenomegaly caused by hepatitis B cirrhosis-related portal hypertension without esophageal varices (Figure 1). Her postoperative course was uneventful, and she was discharged 14 days after her operation. Due to her non-compliance, she was not administered the immunoprophylaxis vaccination. Immediately before her onset of fever, she had taken a sponge bath. Acetaminophen did not relieve the fever, and she was admitted to the local hospital 3 hours later when her temperature was 40.5ˇăC. Her physicians only treated the fever and did not administer antibiotics. Three hours later she became disoriented, astatic, and incontinent of urine. At this time she was admitted to our hospital. On initial physical examination, her temperature was 38.2ˇăC; blood pressure, 52/26 mm Hg; pulse rate, 130 beats/min; and respiratory rate, 24 b
%K Overwhelming Postsplenectomy Infection
%K Mycoplasma Pneumoniae
%K DIC
%K ARDS
%U http://www.biomedcentral.com/1471-2334/11/162