%0 Journal Article
%T T- cell prolymphocytic leukemia - A rare case
%A Ghosh Sharmila
%A Advani Suresh
%J Indian Journal of Cancer
%D 2005
%I Medknow Publications
%X T- cell Prolymhocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy that is usually reported in the elderly and follows an aggressive course. A 68 year old male presented with a history of weakness and weight loss of two months duration. Clinical examination revealed pallor, enlarged cervical and axillary lymph nodes and splenomegaly. He also had a maculo- papular skin rash. There was marked leucocytosis, anemia and thrombocytopenia (WBC 445 x103sub/ml, Hb 8.5gm/dl, Platelet 25x103/¦Ìl) with 60% prolymphocytes in the peripheral blood. Bone marrow was hypercellular with an excess of prolymphocytes. Flow cytometric analysis of the bone marrow showed positivity for CD2, CD3, CD4, CD5 and CD7. T- PLL is a rare T cell disorder with characteristic clinical and laboratory features.Currently, no optimal treatment exists although there has been some success with 2¡ä- deoxycoformycin or Campath-1H
%K Prolymphocytes
%K Leukemia
%K T cell
%K Lymphoproliferative
%U http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2005;volume=42;issue=2;spage=104;epage=106;aulast=Ghosh