%0 Journal Article
%T Differential expression of CD300a/c on human TH1 and TH17 cells
%A Venkateswara R Simhadri
%A John L Mariano
%A Qing Zhou
%A Karen E DeBell
%A Francisco Borrego
%J BMC Immunology
%D 2011
%I BioMed Central
%R 10.1186/1471-2172-12-62
%X Extensive phenotypical and functional characterization showed that in both TCM and TEM cells, the CD300a/c+ subset contained a higher number of TH1 (IFN-¦Ã producing) cells. Alternatively, TH17 (IL-17a producing) cells tend to be CD300a/c-, especially in the TEM subset. Further characterization of the IL-17a+ cells showed that cells that produce only this cytokine are mostly CD300a/c-, while cells that produce IL-17a in combination with other cytokines, especially IFN-¦Ã, are mostly CD300a/c+, indicating that the expression of this receptor is associated with cells that produce IFN-¦Ã. Co-ligation of the TCR and CD300a/c in CD4+ T cells inhibited Ca2+ mobilization evoked by TCR ligation alone and modulated IFN-¦Ã production on TH1 polarized cells.We conclude that the CD300a/c receptors are differentially expressed on human TH1 and TH17 cells and that their ligation is capable of modulating TCR mediated signals.Upon encounter with the antigen in secondary lymphoid tissues, na£¿ve CD4+ T cells initiate a vigorous clonal expansion. This expansion leads to the differentiation and specialization into functionally distinct T helper (TH) cell subsets or lineages. Each TH subset is involved in tailoring immune responses specific to a wide range of antigens. They are characterized by the expression of specific cell surface receptors, and distinct transcription factors that lead to the secretion of a particular set of cytokines [1]. For example, TH1 cells express the transcription factor T-bet and secrete IFN-¦Ã, TNF-¦Á and IL-2. They also express the chemokine receptors CCR5 and CXCR3 and the cytokine receptors IL-12R¦Â2 and IL-18R¦Á. TH1 cells play an important role in the resistance against intracellular pathogens and in the pathogenesis and maintenance of certain autoimmune diseases [2-13]. Another TH subset, TH17 cells, express the transcription factor ROR¦Ãt, secrete IL-17a, IL-17f and IL-22 and are characterized by the expression of the chemokine receptor CCR6, the cytokine rece
%U http://www.biomedcentral.com/1471-2172/12/62