%0 Journal Article
%T Helicobacter pylori infection in relation to gastric cancer progression
%A Venkateshwari A
%A Krishnaveni D
%A Venugopal S
%A Shashikumar P
%J Indian Journal of Cancer
%D 2011
%I Medknow Publications
%X Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.
%K Cytotoxicity associated pathogenicity Island
%K gastric cancer
%K H. pylori
%K ice A gene
%K vacuolating cytotoxin
%U http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2011;volume=48;issue=1;spage=94;epage=98;aulast=Venkateshwari