%0 Journal Article
%T Identifying Metabolic Syndrome in African American Children Using Fasting HOMA-IR in Place of Glucose
%A Sushma Sharma
%A PhD
%A Robert H. Lustig
%A MD
%A Sharon E. Fleming
%A PhD
%J Preventing Chronic Disease
%D 2011
%I National Center for Chronic Disease Prevention and Health Promotion
%X IntroductionMetabolic syndrome (MetS) is increasing among young people. We compared the use of homeostasis model assessment of insulin resistance (HOMA-IR) with the use of fasting blood glucose to identify MetS in African American children.MethodsWe performed a cross-sectional analysis of data from a sample of 105 children (45 boys, 60 girls) aged 9 to 13 years with body mass indexes at or above the 85th percentile for age and sex. Waist circumference, blood pressure, and fasting levels of blood glucose, insulin, triglycerides, and high-density lipoprotein cholesterol were measured.ResultsWe found that HOMA-IR is a stronger indicator of MetS in children than blood glucose. Using HOMA-IR as 1 of the 5 components, we found a 38% prevalence of MetS in this sample of African American children and the proportion of false negatives decreased from 94% with blood glucose alone to 13% with HOMA-IR. The prevalence of MetS was higher in obese than overweight children and higher among girls than boys.ConclusionUsing HOMA-IR was preferred to fasting blood glucose because insulin resistance was more significantly interrelated with the other 4 MetS components.
%K metabolic syndrome
%K metabolic syndrome and African American Children
%K Fasting HOMA-IR
%K Glucose
%K African American child health
%U http://www.cdc.gov/pcd/issues/2011/may/10_0036.htm