%0 Journal Article
%T Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients
%A Aysenur Ozturk
%A Yonca Egin
%A Gulhis Deda
%A Serap Teber
%J Turkish Journal of Hematology
%D 2008
%I Galenos Yayinevi
%X Objective: Protein Z (PZ) plays an enhancer role in coagulation as an anticoagulant. In this study G79A polymorphism was investigated in Turkish pediatric stroke patients. Material and Methods: Ninety-one pediatric stroke patients with cerebral ischemia and 70 control subjects were analyzed for PZ G79A and also factor V Leiden (FVL) and prothrombin (PT) mutations. Results: PZ 79 ¡®A¡¯ allele in homozygous state was found in five patients (5.5%), while it was found in only one control subject (1.4%), and it appeared to be a risk factor for pediatric ischemia [OR=3.94 (0.44-35.1)]. When patients and controls who had FVL and PT carriers were excluded, AA genotype carried a risk [OR=3.88 (0.41-36.5)]. In addition, plasma PZ levels were measured in 21 stroke patients and 52 controls. Plasma PZ levels were not different between stroke patients (501,0 ngml-1 ¡À 158,3 ngml-1) and controls (447,3 ngml-1 ¡À 166,0 ngml-1). However, the plasma levels of PZ were decreased in patients with AA genotype. This is the first study in which G79A polymorphism was investigated in Turkish pediatric stroke patientsConclusion: Our data showed that carrying 79 AA genotype could be a genetic risk factor for cerebral infarct in pediatric patients.
%K Protein Z
%K PROZ
%K G79A polymorphism
%K pediatric stroke.
%U http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-32032