%0 Journal Article
%T The levels of nitric oxide in beta-thalassemia minor
%A Nihayet Bayraktar
%A Mehmet Ali Erkurt
%A £¿smet Aydo£¿du
%A Yal£¿£¿n Ba£¿aran
%J Turkish Journal of Hematology
%D 2008
%I Galenos Yayinevi
%X OBJECTIVE: The aim of this study was to investigate the relationship between NO (nitric oxide) and beta-thalassemia minor. METHODS: A total of 60 patients with beta-thalassemia minor (30 M, 30 F) were included in the study. The control group consisted of 60 healthy subjects (30 M, 30 F). Plasma nitrite/nitrate levels were measured using the Griess reaction method and analyzed by spectrophotometry at 545 nm.RESULTS: Plasma direct nitrite, total nitrite and nitrate levels were 7.561¡À6.19, 42.548¡À7.37 and 34.84¡À6.24 in beta-thalassemia minor patients versus 36.9¡À19.8, 85.9¡À35.3 and 48.61¡À17.35 ¨¬mol/dl in controls, respectively. Plasma direct nitrite, total nitrite and nitrate levels were significantly lower in beta-thalassemia minor patients compared with the control group (p<0.001). CONCLUSION: These findings confirm that plasma NO levels in beta-thalassemia minor patients are decreased at the time of diagnosis. This may be helpful in assessing the prognosis and follow-up evaluation of patients with beta-thalassemia minor.
%K Thalassemia
%K nitric oxide
%K hemoglobin
%K hemolysis
%U http://www.tjh.com.tr/jvi.asp?pdir=tjh&plng=eng&un=TJH-19483&look4=