%0 Journal Article
%T Ayahuasca: uma revis o dos aspectos farmacol車gicos e toxicol車gicos
%A Ana Paula Salum Pires
%A Carolina Dizioli Rodrigues Oliveira
%A Mauricio Yonamine
%J Revista de Ci那ncias Farmac那uticas B芍sica e Aplicada
%D 2010
%I Universidade Estadual Paulista
%X A ayahuasca 谷 uma bebida psicoativa originariamente utilizada em rituais de tribos ind赤genas da regi o amaz nica. Esta bebida 谷 preparada pela infus o de caules da Banisteriopsis caapi Morton, que cont谷m 汕-carbolinas que s o inibidoras da monoaminoxidase (MAO), e de folhas da Psychotria viridis Ruiz & Pav車n, que cont谷m o alucin車geno N,N-dimetiltriptamina (DMT). A enzima MAO degrada a DMT no f赤gado e intestino. No Brasil, a ayahuasca tem sido incorporada em rituais de grupos sincr谷ticos religiosos e seu uso dentro do contexto religioso 谷 amparado por lei federal. Atualmente, esses grupos t那m se espalhado na Europa e Estados Unidos, chamando a aten  o de pesquisadores internacionais quanto aos efeitos da ayahuasca. Estudos t那m indicado que a ayahuasca poderia ter aplica  es terap那uticas como no tratamento da farmacodepend那ncia e at谷 sugerem seu uso seguro por adultos sadios. Entretanto, poucos estudos t那m sido conduzidos para melhor avalia  o de suas propriedades. O objetivo do artigo 谷 mostrar uma revis o geral da hist車ria at谷 as recentes descobertas envolvendo a farmacologia e a toxicologia da ayahuasca. Palavras-chave: Ayahuasca. Alucin車genos. Dimetiltriptamina. Carbolinas. ABSTRACT Ayahuasca: a review of pharmacological and toxicological aspects Ayahuasca (or caapi in Brazil) is a psychoactive plant beverage initially used by shamans in religious rituals practiced by indigenous peoples in the Amazon region. It is prepared by infusing the pounded stems of Banisteriopsis caapi Morton, a liana which contains betacarbolines, alkaloids that are potent monoamine oxidase (MAO) inhibitors, together with the leaves of Psychotria viridis Ruiz & Pav車n, which contains the psychedelic agent N,N-dimethyltryptamine (DMT). The enzyme MAO normally degrades DMT in the liver and gut. In Brazil, the use of ayahuasca within religious ceremonies is protected by law and it has been incorporated into rituals of syncretic religious groups. Some of these groups have established themselves in the United States and European countries, attracting international research interest in the effects of ayahuasca. Studies suggest that it may have therapeutic applications, such as in the treatment of drug addiction, and that it can be used safely by healthy adults. However, too few studies have been performed for a good assessment of its properties to be made. The aim of this article is to present a review of the history of ayahuasca, up to the recent discoveries concerning its pharmacology and toxicology. Keywords: Ayahuasca. Hallucinogens. Dimethyltryptamine. Carbolines.
%K ayahuasca
%K alucin車genos
%K dimetiltriptamina
%K carbolinas
%U http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/888