%0 Journal Article
%T Efeito da massa molar do acetobutirato de celulose e da adi  o de poli(3-hidroxibutirato) sobre as caracter¨ªsticas das microesferas e o prolongamento da libera  o do cetoprofeno
%A BRUNA SILVA de OLIVEIRA
%A CAMILA DETZEL FLEITH
%A MELISSA Z¨¦TOLA
%A BIANCA RAMOS PEZZINI
%J Revista de Ci¨ºncias Farmac¨ºuticas B¨¢sica e Aplicada
%D 2011
%I Universidade Estadual Paulista
%X No presente trabalho, foram elaboradas microesferas de acetobutirato de celulose (ABC) contendo cetoprofeno com o objetivo de prolongar a libera  o do f¨¢rmaco. Utilizou-se a t¨¦cnica de emuls o e evapora  o do solvente, variando-se os seguintes parametros: massa molar do ABC e a adi  o ou n o de poli(3-hidroxibutirato) (PHB), segundo um planejamento fatorial 22. Maiores efici¨ºncias de encapsula  o do cetoprofeno foram obtidas quando utilizado ABC com maior massa molar e a adi  o do PHB levou a uma diminui  o do percentual de f¨¢rmaco encapsulado. Todas as formula  es originaram part¨ªculas esf¨¦ricas, com cristais de f¨¢rmacos aderidos ¨¤ superf¨ªcie externa e matriz polim¨¦rica porosa quando adicionado o PHB. Os perfis de libera  o in vitro indicaram que o aumento da massa molar do ABC levou a uma diminui  o do percentual de f¨¢rmaco inicialmente liberado e a um prolongamento de sua libera  o. Por outro lado, a adi  o do PHB acelerou a libera  o do cetoprofeno a partir das microesferas. Palavras-chave: Microesferas. Cetoprofeno. Prepara  es de libera  o retardada. ABSTRACT Effects of cellulose acetate butyrate molar weight and addition of poly(3-hydroxybutyrate) on microsphere morphology and ketoprofen prolonged release In the present study, cellulose acetate butyrate (CAB) microspheres containing ketoprofen were produced, with the objective of prolonging its release. The emulsion/solvent evaporation technique was used to make the spheres, varying the parameters (1) CAB molecular weight and (2) addition or not of poly(3-hydroxybutyrate) [PHB], to optimize drug encapsulation, following a 22 factorial design. Higher ketoprofen encapsulation efficiency was obtained when higher molecular weight CAB was used, while the addition of PHB caused a decrease in the percentage of encapsulated drug. All the preparations produced spherical particles, with drug crystals adhering to the external surface, and a porous polymer matrix when PHB was used. The in vitro release profiles indicated that lowering the CAB molecular weight led to a decrease in the drug initially released and a prolonged release. On the other hand, the addition of PHB accelerated the release of the ketoprofen from the microspheres. Keywords: microspheres. Ketoprofen. Delayed-release preparations.
%K microesferas
%K cetoprofeno
%K sistemas de libera  o prolongada.
%U http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/1355