%0 Journal Article
%T Blood immunological parameters upon hypoxic-ischemic injuries of central nervous system in newborns and infants
%A Gulomjan Khalimbetov
%J Medical and Health Science Journal
%D 2012
%I Prague Development Center
%X The paper studies interrelation between immune system condition and circulating concentrations of neuropeptides and neuron-specific enolase (NSE) upon perinatal pathology in newborns and infants. Reactivity of cytokine and interleukin links of immune systems was found varying in newborns and infants with CNS hypoxic-ischemic pathology, accompanied by psychomotor retardation, a psycho-speech disorder, emotional and behavioral disorders (EBD) and paroxysmal syndrome. At admission irrespectively of a syndrome type in the patients with CNS hypoxic-ischemic pathology, as compared with the patients in the control group, circulating TNF-¦Á and IL-1 were found increased by 3.4-4.1 and 6.4-7.9 times, respectively. Release of S100 protein and NSE seems to be the underlying mechanism for enhancement of synthesis and/or release of TNF-¦Á and IL-1 into circulation of patients with CNS hypoxic-ischemic pathology.
%K Cytokine
%K interleukin
%K hypoxic-ischemic CNS pathology
%U http://academicpublishingplatforms.com/article.php?journal=MHSJ&number=11&article=1390