%0 Journal Article
%T The relation between brain natriuretic peptide and patent ductus arteriosus in premature infants
%A Selcen Yaro£¿lu Kazanc£¿
%A Alper G¨¹zelta£¿
%A Sultan Kavucuo£¿lu
%J Turk Pediatri Ar£¿ivi
%D 2012
%I Galenos Yayincilik
%X Aim: To compare brain natriuretic peptide level and some of the echocardiographic parameters of premature infants and to search its value for the diagnosis of patent ductus arteriosus.Material and Method: Fifty infants born before the 34th gestational week in the neonatology clinic of Bak rkoy Obstetrics and Children¡¯s Educational Hospital between March 2009 and August 2009 were inspected prospectively. Patients with patent ductus arteriosus constituted Grup 1 (n=20) and patients without patent ductus arteriosus constituted Grup 2 (n=30). The diagnosis of patent ductus arteriosus was made by M-mode and Doppler echocardiography on the 7th day postnatally. Ductus diameter, left atrium aortic root diameter ratio, left ventricular end diastolic diameter, interventricular septum thickness, left ventricular posterior wall thickness, ejection fraction and fractional shortening were evaluated. The infants with hemodynamically significant patent ductus arteriosus were treated.Brain natriuretic peptide was evaluated on the 1st, 3rd and 7th days of postnatal age in all patients and also on the 3rd day after treatment. For statistical analysis SPSS for Windows 15.0 was used. The study was conducted after obtaining informed consent from the patients and was approved with the decision of the ethics commitee (number 231, date 12-6-2009). Results: Sex, gestational age and birth weight were similar in both grups. When brain natriuretic peptide level was compared with ductus diameter, left atrium aortic root diameter ratio and left ventricular end diastolic diameter values, the results were found to be statistically significant (p<0.05). When comparison was made with interventricular septum thickness, left ventricular posterior wall thickness, ejection fraction and fractional shortening values, the results were found to be statistically insignificant (p>0.05). Brain natriuretic peptide level decreased significantly after treatment.Conclusions: Brain natriuretic peptide level was found be higher in infants with patent ductus arteriosus compared to infants without patent ductus arteriosus. It was shown that ductus diameter, left atrium aortic root diameter ratio and left ventricular end diastolic diameter were related with brain natriuretic peptide levels. (Turk Arch Ped 2012; 47: 90-4)
%K Atrial natriuretic peptide
%K brain natriuretic peptide
%K echocardiograph
%K left atrium aortic root diameter ratio
%K left ventricular end diastolic diameter
%K patent ductus arteriosus
%K premature infant
%U http://www.turkpediatriarsivi.com/eng/makale/1387/126/Full-Text