%0 Journal Article
%T An in vivo model to study the anti-malaric capacity of plant extracts
%A Misael Chinchilla
%A Olga M. Guerrero
%A Gabriela Abarca
%A Mariano Barrios
%J Revista de Biolog¨Şa Tropical
%D 1998
%I Universidad de Costa Rica
%X An in vivo model to study the antimalaric effect of plant extracts is described. White mice (25-30g body weight) are treated subcutaneously with 0.6ml of the diluted extract starting seven days before P. berghei infection; treatment continues until death or for 30 days. Simultaneously 0.2ml of the extract are applied per os starting three days before infection. In a test of the model, treated and non-treated animals differed in body weight, survival time, haematocrite, parasitemia development, and spleen or liver weight of recent dead or killed mice.
%K Malaria
%K Plasmodium berghei
%K treatment
%K plants
%U http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0034-77441998000100003