%0 Journal Article
%T Tuberculosis Frequency in Patients Taking TNF-alpha Blokers
%A Co£¿kun Do£¿an
%A Nesrin K£¿ral
%A Sevda £¿ener C£¿mert
%A Ali Fidan
%J Turk Toraks Dergisi
%D 2012
%I Aves Yayincilik
%X Objective: To evaluate tuberculosis frequency in patients who take tumor necrosis factor alpha (TNF-¦Á) inhibitors for Collagen Vascular Disease (CVD).Materials and Methods: Patients who actively use or were planned to use TNF-¦Á inhibitors for CVD between June 2007-February 2010 were prospectively included in the study.All patients had a physical examination, chest x-ray and the Tuberculin Skin Test (TST). Sputum smear and culture for acid fast bacilli (AFB) was performed in patients with a suspicious lesion on chest x-ray. During follow-up, physical examination, chest x-ray and sputum smear for AFB in indicated cases were performed every 3 months. Tuberculosis was diagnosed with microbiological, radiological and histopathological methods.In case of pulmonary or extrapulmonary tuberculosis,TNF-¦Á inhibitor medication was stopped and anti-tuberculosis therapy was began.Results: A total of 179 patients were included in the study, 91 were female and 88 were male wth a mean age of 42.8¡À12.0. In 141 patients, TNF-¦Á inhibitor therapy was begun in the study although 38 were taking TNF-¦Á inhibitor medication at the beginning of the study. The median follow-up period was 17 months and 2 (1.1%) patients were diagnosed to have active tuberculosis during the study period. The TST was found to be 5-9 mm in 15% and >10 mm in 53.3% of the patients.There was a successful tuberculosis therapy history in 5 patients and at least 1 BCG scar was seen in 67 patients.In our series, 70.9% of the patients had chemoprophylaxis during the study period and new tuberculosis was diagnosed in 2 patients, consisting of one miliary tuberculosis and one pleural tuberculosis. Tuberculosis was diagnosed in 1.1% of TNF-alpha taking patients in our series. Conclusion: It is recomended that the patients taking anti TNF treatment should be evaluated and followed up regularly for tuberculosis during the treatment.
%K Spondylitis
%K ankylosing
%K arthritis
%K rheumatoid
%K tuberculin test
%K tuberculosis
%K tumor necrosis factor-alpha
%U http://toraks.dergisi.org/text.php3?id=841