%0 Journal Article
%T Signet Ring Lobular Carcinoma in Situ as a Part of the ¡°Rosen Triad¡± (Tubular Carcinoma, Columnar Cell Hyperplasia, and Lobular Carcinoma in Situ)
%A Josko BEZIC
%A Dijana GUGIC
%J Tš¹rk Patoloji Dergisi
%D 2013
%I Federation of Turkish Society of Pathology
%R 10.5146/tjpath.2013.01164
%X Objective: The association of tubular carcinoma, columnar cell lesions and lobular carcinoma in situ, also known as the ¡°Rosen Triad¡±, may be encountered in breast biopsies performed for evaluation of mammographically detected microcalcifications.Case Report: A case in which tubular carcinoma and columnar cell hyperplasia were associated with a histologically unusual form of signet ring lobular carcinoma in situ is presented. Signet ring non-invasive lobular carcinoma is classified as high-grade lobular carcinoma in situ, but herein is associated with changes that belong to the molecular pathway of low-grade mammary neoplasia.Conclusion: We reported the case of lobular carcinoma in situ associated with columnar cell hyperplasia and tubular carcinoma, in which the lobular carcinoma in situ was presented in a histologically unexpected form comprised predominantly of signet ring cells.
%K Breast
%K Carcinoma
%K Signet ring cell
%K Carcinoma in situ
%U http://www.turkjpath.org/pdf.php3?id=1591