%0 Journal Article
%T Efficacy of Continuous High Dose Midazolam Infusion in Childhood Refractory Generalized Convulsive Status Epilepticus
%A Afshin Fayyazi
%A Parvaneh Karimzadeh
%J Iranian Journal of Child Neurology
%D 2011
%I Iranian Child Neurology Society
%X bjeciveProlonged and uncontrolled refractory status epilepticus (SE) is a life-threatening medical emergency in children (1,2,3). There is no consensus on the optimal therapy for refractory status epilepticus (1). The aim of this study was to develop a new method for treating patients with refractory status epilepticus.Materials & MethodsTen children with refractory status epilepticus in Mofid Hospital, who did not respond to 10 ¦Ìg/kg per min of intravenous midazolam, had their dose of midazolam increased to 30 ¦Ìg/kg per min. All children were monitored for the development of side effects.ResultsTen children with no response to low-dose midazolam were given a higher dose of midazolam, and 5 (50%) children had a good response. These patients had significantly different response to high-dose midazolam.One patient in the high-dose midazolam group was intubated and required mechanical ventilation. The duration of stay in the hospital and PICU and on mechanical ventilation in patients with no response to low-dose midazolam following with other drugs was longer than in the high-dose midazolam group.No death occurred in high dose midazolam group.ConclusionHigh-midazolam dose drip infusion is a safe and effective protocol for refractory status epilepticus in children.
%K Refractory status epilepticus
%K midazolam
%K mortality
%K childhood
%U http://journals.sbmu.ac.ir/ijcn/article/view/2401/2081