%0 Journal Article
%T C谷lulas ovales en el h赤gado de ratas con lesiones quir迆rgicas severas Oval cells in the liver of rats with severe surgical lesions
%A J. Sarradell
%A F.M. Rondelli
%A J.C. Hrdalo
%A J. Fiorentini
%J InVet
%D 2010
%I Universidad de Buenos Aires
%X Se realizaron intervenciones quir迆rgicas para visualizar histol車gicamente la presentaci車n y la intervenci車n de c谷lulas madre en la restituci車n tisular hep芍tica de ratas hepatectomizadas. Se trabaj車 con dos grupos de animales: en uno se realiz車 hepatectom赤as leves, y en el otro, hepatectom赤as severas. En el primer grupo se observ車 una cicatrizaci車n del tejido injuriado, a diferencia del segundo grupo donde se verifi c車 una masiva proliferaci車n de conductos biliares de trayecto sinuoso, que generaron abundantes prolongaciones sat谷lites. Tambi谷n se observ車 gran cantidad de c谷lulas de morfolog赤a compatible con c谷lulas ovales (n迆cleo y citoplasma ovales y relaci車n n迆cleo citoplasma aumentada). Podemos concluir que la reparaci車n hep芍tica tras un da o menor se hace por la proliferaci車n de c谷lulas diferenciadas; en cambio, los da os mayores inician un proceso de reparaci車n por c谷lulas indiferenciadas progenitoras que generar芍n luego, hepatocitos y c谷lulas ductales. Surgical experiences to histologically visualize the presentation and intervention of stem cells in the hepatic cellular healing of rats were drawn. In one experience the hepatic tissue was slightly injured and in other group severe lesion was done. In the fi rst group there was scaring. In the second group there was massive proliferation of biliary ducts of sinuous tract generating abundant satellital extensions when the lesion was severe. In relation to these structures, a great quantity of cells being morphologically compatible with hepatic oval cells (oval nucleus and cytoplasm and large nucleus to cytoplasm ratio) were observed. In conclusion the hepatic healing after a lesser damage is made by proliferation of differentiated cells and extreme damages begin healing by non-differentiated stem cells from biliary ducts generating hepatocytes and ductal cells.
%K H赤gado
%K C谷lulas ovales
%K Lesiones quir迆rgicas
%K Histopatolog赤a
%K Liver
%K Oval cells
%K Surgical lesions
%K Histopathology
%U http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-34982010000100003