%0 Journal Article
%T Systemic-Lupus-Erythematosus-Related Acute Pancreatitis: A Cohort from South China
%A Yanlong Yang
%A Yujin Ye
%A Liuqin Liang
%A Tianfu Wu
%A Zhongping Zhan
%A Xiuyan Yang
%A Hanshi Xu
%J Clinical and Developmental Immunology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/568564
%X Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China. Methods. Inpatient medical records of SLE-related AP were retrospectively reviewed. Results. 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score (21.70¡À10.32 versus 16.17¡À7.51, =0.03), more organ systems involvement (5.70¡À1.56 versus 3.96¡À1.15, =0.001), and higher mortality (37.04% versus 0, =0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, =0.014). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis. Conclusion. SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP.
%U http://www.hindawi.com/journals/cdi/2012/568564/