%0 Journal Article
%T Polimorfismos gen¨¦ticos do sistema renina-angiotensina-aldosterona na doen a arterial coronariana e na hipertens o arterial sist¨ºmica
%A Ricardo BONFIM-SILVA
%A Domingos L¨¢zaro SOUZA-RIOS
%J Revista da Universidade Vale do Rio Verde
%D 2012
%I Universidade Vale do Rio Verde
%X Hypertension is considered a risk factor for coronary artery disease (CAD). Hypertension andatherosclerosis are the two major diseases of the arterial system and are closely associated. The renin-angiotensinaldosteronesystem (RAAS) has been identified as a critical path for the control of blood pressure and kidney function.This system has an important role in regulating blood pressure by influencing homeostasis salt / water and thereforehaving an intimate relationship with the process of hypertension. Since hypertension emerges as a risk factor for CAD,the RAAS is also related to this disease. Most human diseases are polygenic and multifactorial, they are governed bymany genes and caused by a combination of factors acting together and simultaneously. Due to the strong relationshipalready mentioned between RAAS and hypertension and CAD, polymorphisms in candidate genes of this system, aswell as polymorphisms in the angiotensin converting enzyme gene (ACE) and angiotensinogen gene (AGT) have beenanalyzed extensible as genetics determinants of these diseases. Studies of genetic polymorphisms have severalfunctions, among them the determination of molecular markers linked to disease development. This becomes importantbecause the development of molecular markers may lead to a new prognosis. In the case of CAD and hypertension,changes in the RAAS are closely related to the occurrence of these diseases, and consequently polymorphisms in genesthat control this system can direct us to understand how the genetic influences the development of these diseases.
%K hypertension. coronary artery disease. angiotensin converting enzyme. angiotensinogen. polymorphisms.
%U http://revistas.unincor.br/index.php/revistaunincor/article/view/240