%0 Journal Article
%T immune response of T cells in cutaneous leishmaniosis Respuesta inmune de c谷lulas T en leishmaniosis cut芍nea
%A Claudia Milena Trujillo Vargas
%A Pablo Javier Patiˋo Grajales
%J Iatreia
%D 1998
%I Universidad de Antioquia
%X The role of TCD4+ cell subsets, Th1 and Th2, has been studied in the infection by Leishmania major in the murine model. The development of the Th1 phenotype in inbred strains of mice (cells that mainly secrete IL.2, IFN.y and TNF.13) are associated with resistance to L. major infection. In contrast, Th2 phenotype (cells that mainly secrete IL.4, IL.5, IL.6, IL.10 and IL.13) are associated with susceptibility to the infection. Recent data suggest than IL.4 appears to be essential for the priming and maturation of Th2 cells while IL.12 enhances the maturation of Th1 cells. In addition, IL.4 and IFN.y exert opposite regulatory effects on Th1 and Th2 cells, respectively. Recent findings have clearly established that the CD8+ T cell subpopulations also contribute to the resolution of the disease and resistance against infection. In humans, although the specific immune response against the parasite is less polarized than in mice, there is a clear tendency to the development of the Th1 phenotype in the mild forms of cutaneous infection. Identification of specific Leishmania.reactive T cell subpopulations in susceptible and resistant individuals should lead to the development of appropriate in vitro assays that could be used for the identification of Leishmania antigens against which a protective immune response is elicited to test as potential vaccine candidates. El papel de las sub poblaciones de c谷lulas TCD4+, Th1 y Th2, ha sido bien estudiado en la infecci車n por Leishmania major en el modelo murino experimental. Las cepas sing谷nicas de ratones que desarrollan el fenotipo Th1 (c谷lulas que secretan principalmente IL-2, IFN-y y TNF-!3) son resistentes a la infecci車n por este protozoo. En contraste, las que desarrollan el fenotipo Th2 (c谷lulas que secretan principalmente IL-4, IL-5, IL-6, IL-10 e IL-13) son susceptibles a ella. Los estudios recientes indican que la IL-4 es una se al esencial en la estimulaci車n primaria y maduraci車n de las c谷lulas Th2, mientras que IL-12 permite la maduraci車n de las c谷lulas Th1. Adicionalmente, IL.4 e IFN-y ejercen efectos reguladores opuestos sobre las c谷lulas Th1 y Th2 respectivamente. Por otra parte, varios estudios han establecido claramente que la subpoblaci車n de linfocitos TCD8+ tambi谷n contribuye a la resoluci車n de la enfermedad y la resistencia contra la reinfecci車n en leishmaniosis cut芍nea. En los humanos, aunque la respuesta inmune dirigida contra el par芍sito es menos polarizada que en el rat車n, se ha evidenciado una clara tendencia hacia la producci車n del fenotipo Th1 en las formas menos severas de la enfermedad. La i
%K leishmaniosis cut芍nea
%K c谷lulas t cd4+: c谷lulas th1: c谷lulas th2
%U http://www.iatreia.udea.edu.co/index.php/iatreia/article/view/407