%0 Journal Article %T Second-hand Smoke Increases Nitric Oxide and Alters the IgE Response in a Murine Model of Allergic Aspergillosis %A Brian W. P. Seymour %A Janice L. Peake %A Kent E. Pinkerton %A Viswanath P. Kurup %A Laurel J. Gershwin %J Clinical and Developmental Immunology %D 2005 %I Hindawi Publishing Corporation %R 10.1080/17402520500116806 %X This study was performed to determine the effects of environmental tobacco smoke (ETS) on nitric oxide (NO) and immunoglobulin (Ig) production in a murine model of allergic bronchopulmonary aspergillosis (ABPA). Adult BALB/c mice were exposed to aged and diluted sidestream cigarette smoke from day 0 through day 43 to simulate “second-hand smoke”. During exposure, mice were sensitized to soluble Aspergillus fumigatus (Af) antigen intranasally between day 14 and 24. All Af sensitized mice in ambient air (Af %U http://www.hindawi.com/journals/cdi/2005/549410/abs/