%0 Journal Article
%T SNP Analysis of Genes Implicated in T Cell Proliferation in Primary Biliary Cirrhosis
%A Sabine Oertelt
%A Thomas P. Kenny
%A Carlo Selmi
%A Pietro Invernizzi
%A Mauro Podda
%A M. Eric Gershwin
%J Clinical and Developmental Immunology
%D 2005
%I Hindawi Publishing Corporation
%R 10.1080/17402520500317859
%X Previous studies on primary biliary cirrhosis (PBC) have focused on the role of T lymphocytes as potential effectors of tissue injury. We hypothesized that single nucleotide polymorphisms (SNPs) of genes involved in lymphocyte proliferation would be responsible for uncontrolled expansion of T cells and autoreactivity. To address this, we genotyped DNA from 154 patients with PBC and 166 ethnically matched healthy controls for SNPs of five candidate genes (60G/A CTLA-4, 1858 C/T LYP, -IVS9 C/T foxp3, p1323 C/G ICOS and -9606 T/C CD25) using a TaqMan assay.
%U http://www.hindawi.com/journals/cdi/2005/297598/abs/