%0 Journal Article
%T Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells
%A Muthusamy Kunnimalaiyaan
%A Megan R. Haymart
%A Herbert Chen
%J Translational Oncogenomics
%D 2007
%I 
%X There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
%K medullary thyroid cancer
%K Notch1
%K Raf-1
%K achaete scute complex-like 1
%K Notch1 activating compound
%K ZM336372
%U http://la-press.com/article.php?article_id=234