%0 Journal Article
%T Formulation and Evaluation of Floating tablets of Theophylline
%A C.Bijumol
%A Helen William
%A Jose Kurien and Thomas Kurian
%J Hygeia : Journal for Drugs and Medicines
%D 2013
%I 
%X Plan: Formulation of oral gastro retentive floating tablets ofTheophylline.Prologue: The primary aim of the present study is to design a sustainedrelease gastro retentive oral dosage form using intra gastric floating asformulation strategy. Theophylline, an antiasthmatic is used as the model drug.Methodology: Oral gastro retentivefloating tablets of Theophylline was formulated using gel-forming hydrophilicpolymers, HPMCK4M, HPMCK100M and HPMC 15cps. The work also focused on in vivoevaluation of buoyancy by x-ray imaging. Suitable In vitro methods forestimating the drug release from the tablet as a function of time weredeveloped and compared with marketed product (TheoSR200mg)Outcome: The prepared Tablets exhibited satisfactory physicochemicalcharacteristics. All the prepared batches showed good in vitro buoyancy. Thetablets with HPMCK4M and HPMCK100M floated for longer duration and had morematrix integrity as compared to formulations containing HPMC 15cps. Formulationswith HPMCK100M & HPMCK4M showed better control of drug release and the drugrelease was similar to that of marketed product.
%K Theophylline
%K Gastro retentive floating tablets
%K Polymers HPMCK4M
%K HPMCK100M and HPMC 15cps.
%U http://www.hygeiajournal.com/Downloads/8852175775.C.Bijumol%20-Formulationrevised.pdf