%0 Journal Article
%T Neural network models of protein domain evolution
%A Sylvia Nagl
%J Hyle : International Journal for Philosophy of Chemistry
%D 2000
%I HYLE Publications, Karlsruhe and University of Karlsruhe
%X Protein domains are complex adaptive systems, and here a novel procedure is presented that models the evolution of new functional sites within stable domain folds using neural networks. Neural networks, which were originally developed in cognitive science for the modeling of brain functions, can provide a fruitful methodology for the study of complex systems in general. Ethical implications of developing complex systems models of biomolecules are discussed, with particular reference to molecular medicine.
%K philosophy of chemistry
%K models in biochemistry
%K protein domain evolution
%K neural networks
%K ethics of modeling
%U http://www.hyle.org/journal/issues/6/nagl.pdf