%0 Journal Article
%T Genome-wide association study identified three major QTL for carcass weight including the PLAG1-CHCHD7 QTN for stature in Japanese Black cattle
%A Shota Nishimura
%A Toshio Watanabe
%A Kazunori Mizoshita
%A Ken Tatsuda
%A Tatsuo Fujita
%A Naoto Watanabe
%A Yoshikazu Sugimoto
%A Akiko Takasuga
%J BMC Genetics
%D 2012
%I BioMed Central
%R 10.1186/1471-2156-13-40
%X Bonferroni-corrected genome-wide significant associations were detected in three chromosomal regions on bovine chromosomes (BTA) 6, 8, and 14. The associated single nucleotide polymorphisms (SNP) on BTA 6 were in linkage disequilibrium with the SNP encoding NCAPG Ile442Met, which was previously identified as a candidate quantitative trait nucleotide for CW-2. In contrast, the most highly associated SNP on BTA 14 was located 2.3-Mb centromeric from the previously identified CW-1 region. Linkage disequilibrium mapping led to a revision of the CW-1 region within a 0.9-Mb interval around the associated SNP, and targeted resequencing followed by association analysis highlighted the quantitative trait nucleotides for bovine stature in the PLAG1-CHCHD7 intergenic region. The association on BTA 8 was accounted for by two SNP on the BovineSNP50 BeadChip and corresponded to CW-3, which was simultaneously detected by linkage analyses using half-sib families. The allele substitution effects of CW-1, CW-2, and CW-3 were 28.4, 35.3, and 35.0 kg per allele, respectively.The GWAS revealed the genetic architecture underlying carcass weight variation in Japanese Black cattle in which three major QTL accounted for approximately one-third of the genetic variance.
%K GWAS
%K QTL
%K Carcass weight
%K Body size
%K Body weight
%K Growth trait
%K Cattle
%U http://www.biomedcentral.com/1471-2156/13/40/abstract