%0 Journal Article
%T Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian ¡Á Meishan F2 population
%A Ingrid Balcells
%A Anna Castell¨®
%A Anna Mercad¨¦
%A Jos¨¦ L Noguera
%A Amanda Fern¨¢ndez-Rodr¨ªguez
%A Armand S¨¤nchez
%A Anna Tom¨¤s
%J BMC Genetics
%D 2011
%I BioMed Central
%R 10.1186/1471-2156-12-93
%X The Mucin 4 (MUC4) gene has been evaluated as a candidate gene for a prolificacy QTL described in an Iberian ¡Á Meishan (Ib ¡Á Me) F2 intercross. For association analyses, two previously described SNPs (DQ124298:g.243A>G and DQ124298:g.344A>G) were genotyped in 347 pigs from the Ib ¡Á Me population. QTL for the number of piglets born alive (NBA) and for the total number of piglets born (TNB) were confirmed on SSC13 at positions 44 cM and 51 cM, respectively. The MUC4 gene was successfully located within the confidence intervals of both QTL. Only DQ124298:g.344A>G MUC4 polymorphism was significantly associated with both NBA and TNB (P-value < 0.05) with favourable effects coming from the Meishan origin. MUC4 expression level was determined in F2 sows displaying extreme phenotypes for the number of embryos (NE) at 30-32 days of gestation. Differences in the uterine expression of MUC4 were found between high (NE ¡Ý 13) and low (NE ¡Ü 11) prolificacy sows. Overall, MUC4 expression in high prolificacy sows was almost two-fold increased compared with low prolificacy sows.Our data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation.Prolificacy traits have been widely explored during the last decades as a potential tool for increasing efficiency of sow productivity in the pig industry. Genetic improvement programmes have achieved moderate gains in prolificacy related traits owing to their low heritability, late expression in life and sex limitation [1]. Increasing knowledge on the genetic architecture of prolificacy traits would provide new tools to improve the efficiency of genetic selection by implementing marker assisted selection (MAS).So far a relatively low number of quantitative trait loci (QTL) for prolificacy traits reaching the genome-wide significance level have been identified [2,3]. The most significant QTL affecting the number of piglets born alive (NBA) an
%U http://www.biomedcentral.com/1471-2156/12/93