%0 Journal Article
%T Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs
%A Muhammad Uddin
%A Do Duy
%A Mehmet Cinar
%A Dawit Tesfaye
%A Ernst Tholen
%A Heinz Juengst
%A Christian Looft
%A Karl Schellander
%J BMC Genetics
%D 2011
%I BioMed Central
%R 10.1186/1471-2156-12-62
%X Most of the traits were correlated with each other and were influenced by average daily gain, slaughter date and age. A total of 18 QTL including three QTL with imprinting effect were identified on 11 different porcine autosomes. Most of the QTL reached to 5% chromosome-wide (CW) level significance including a QTL at 5% experiment-wide (GW) and a QTL at 1% GW level significance. Of these QTL four were identified for both the CT and LDL and two QTL were identified for both the TG and LDL. Moreover, three chromosomal regions were detected for the HDL/LDL ratio in this study. One QTL for HDL on SSC2 and two QTL for TG on SSC11 and 17 were detected with imprinting effect. The highly significant QTL (1% GW) was detected for LDL at 82 cM on SSC1, whereas significant QTL (5% GW) was identified for HDL/LDL on SSC1 at 87 cM. Chromosomal regions with pleiotropic effects were detected for correlated traits on SSC1, 7 and 12. Most of the QTL identified for serum lipid traits correspond with the previously reported QTL for similar traits in other mammals. Two novel QTL on SSC16 for HDL and HDL/LDL ratio and an imprinted QTL on SSS17 for TG were detected in the pig for the first time.The newly identified QTL are potentially involved in lipid metabolism. The results of this work shed new light on the genetic background of serum lipid concentrations and these findings will be helpful to identify candidate genes in these QTL regions related to lipid metabolism and serum lipid concentrations in pigs.Cholesterol (CT) is a lipid present in the cell membranes and transported in the bloodstream of all animals. CT is important for the synthesis of cell membrane and hormones and play vital role in the cell signaling process [1]. Cholesterol concentration in high density lipoprotein (HDL) and low density lipoprotein (LDL) are strong predictors for coronary heart disease and obesity. Higher concentration of LDL cholesterol and lower concentration of functional HDL are strongly associated wit
%K pig
%K QTL
%K serum lipids
%K F2 population
%U http://www.biomedcentral.com/1471-2156/12/62