%0 Journal Article
%T Evaluation of Terbinafine Activity on Pneumocystis carinii in the Rat Model
%A M¨¹ge O£¿uzkaya ARTAN
%A Nedret KO£¿
%A Ahmet £¿ZT¨¹RK
%J Trakya Universitesi Tip Fakultesi Dergisi
%D 2010
%I 
%X Objective: The purpose of this study was to test the hypothesis thThis study was planned to investigate the antipneumocystis activity of terbinafine in a rat model.Material and Methods: Rats were obtained from the Hakan  etinsaya Experimental and Clinical Research Institutions, Erciyes University, Kayseri, Turkey. Terbinafine administered orally in doses of 40, 80, 120 and 160 mg/kg/day after nine weeks of immunosuppression with dexamethasone to facilitate the development of acute Pneumocystis carinii penumoniae (PCP). Results: Untreated animals showed P. carinii infection levels with a mean (¡Àstandard deviation) log number of cysts per gram of lung tissue of 4.6¡À1.6 at the end of the experiment. Terbinafine administered at a dose of 160 mg/kg/day significantly reduced the log number of cysts per gram to 2.2¡À1.5. The therapeutic efficacy of terbinafine administered at 160 mg/kg/day (log 2.2¡À1.5 cysts/lung) was similar to that obtained with trimethoprim-sulfamethoxazole (TMP-SMX), 50/250 mg/kg/day (p<0.001). A reduction in the number of cysts was also observed in infected animals treated with 80, and 120 mg of terbinafine/kg/day, although the results were not statistically significant (p>0.05). Conclusion: In our model, the efficacy of terbinafine in PCP has been found to be dose dependent.
%K Pneumocystis carinii
%K rat
%K terbinafine.
%U http://www.tutfd.org/text.php3?id=335