%0 Journal Article
%T The impact of modern migrations on present-day multi-ethnic Argentina as recorded on the mitochondrial DNA genome
%A Mar¨ªa Catelli
%A Vanesa ¨¢lvarez-Iglesias
%A Alberto G¨®mez-Carballa
%A Ana Mosquera-Miguel
%A Carola Romanini
%A Alicia Borosky
%A Jorge Amigo
%A ¨¢ngel Carracedo
%A Carlos Vullo
%A Antonio Salas
%J BMC Genetics
%D 2011
%I BioMed Central
%R 10.1186/1471-2156-12-77
%X Phylogenetic and admixture analyses indicate that only half of the Native American component in urban Argentineans might be attributed to the legacy of extinct ancestral Argentineans and that the Spanish genetic contribution is slightly higher than the Italian one. Entire H2a5 genomes linked these Argentinean mtDNAs to the Basque Country and improved the phylogeny of this Basque autochthonous clade. The fingerprint of African slaves in urban Argentinean mtDNAs was low and it can be phylogeographically attributed predominantly to western African. The European component is significantly more prevalent in the Buenos Aires province, the main gate of entrance for Atlantic immigration to Argentina, while the Native American component is larger in North and South Argentina. AMOVA, Principal Component Analysis and hgs/haplotype patterns in Argentina revealed an important level of genetic sub-structure in the country.Studies aimed to compare mtDNA frequency profiles from different Argentinean geographical regions (e.g., forensic and case-control studies) should take into account the important genetic heterogeneity of the country in order to prevent false positive claims of association in disease studies or inadequate evaluation of forensic evidence.The inhabitation of the Americas took place with the passage of people from northeast Asia to North America, who then rapidly moved southwards along the continent [1-4]. The first human settlements in Argentina were found in the Patagonia and dated to ~13,000 years ago (y.a.) [5]. The colonial period (roughly 1550-1810) began with the arrival of Spanish conquerors, and their domination lasted until the independence wars. During the colonial era, the Spaniards entered Argentina from Peru and Bolivia mainly through the northern 'Camino Real' and by the R¨ªo de la Plata, and they established a permanent colony on the site of what would later become Buenos Aires. R¨ªo de la Plata was also one of the main gates of entrance for other tran
%U http://www.biomedcentral.com/1471-2156/12/77