%0 Journal Article
%T Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle
%A Amanda K Lindholm-Perry
%A Andrea K Sexten
%A Larry A Kuehn
%A Timothy PL Smith
%A D Andy King
%A Steven D Shackelford
%A Tommy L Wheeler
%A Calvin L Ferrell
%A Thomas G Jenkins
%A Warren M Snelling
%A Harvey C Freetly
%J BMC Genetics
%D 2011
%I BioMed Central
%R 10.1186/1471-2156-12-103
%X Animals from the original study were genotyped for 47 SNP within or near the gene boundaries of the three candidate genes. Sixteen markers in the NCAPG-LCORL locus displayed significant association with both ADFI and ADG even after stringent correction for multiple testing (P ¡Ü 005). These markers were evaluated for their effects on meat and carcass traits. The alleles associated with higher ADFI and ADG were also associated with higher hot carcass weight (HCW) and ribeye area (REA), and lower adjusted fat thickness (AFT). A reduced set of markers was genotyped on a separate, crossbred population including genetic contributions from 14 beef cattle breeds. Two of the markers located within the LCORL gene locus remained significant for ADG (P ¡Ü 0.04).Several markers within the NCAPG-LCORL locus were significantly associated with feed intake and body weight gain phenotypes. These markers were also associated with HCW, REA and AFT suggesting that they are involved with lean growth and reduced fat deposition. Additionally, the two markers significant for ADG in the validation population of animals may be more robust for the prediction of ADG and possibly the correlated trait ADFI, across multiple breeds and populations of cattle.Feed intake and average daily gain are economically important phenotypes in beef cattle. The ability to genetically select for animals that better suit a producer's needs in terms of the amount of feed an animal consumes and the gain that can be expected would benefit the industry. However, it is critical that markers used to select for feed and growth traits do not adversely affect other traits including meat quality, carcass traits or reproduction.Quantitative trait loci (QTL) for cattle growth traits such as birth weight, body length, carcass weight, and longissimus muscle area (LMA) have been detected on bovine chromosome 6 in several different populations of animals. Nkrumah et al. [1] discovered a QTL at 42 cM for average daily gain (ADG) i
%U http://www.biomedcentral.com/1471-2156/12/103