%0 Journal Article
%T Polymerized-Type I Collagen Induces Upregulation of Foxp3-Expressing CD4 Regulatory T Cells and Downregulation of IL-17-Producing CD4 T Cells (Th17) Cells in Collagen-Induced Arthritis
%A Janette Furuzawa-Carballeda
%A Perla Macip-Rodr¨ªguez
%A Angeles S. Galindo-Feria
%A David Cruz-Robles
%A Virgina Soto-Abraham
%A Sergio Escobar-Hern¨¢ndez
%A Diana Aguilar
%A Deshir¨¦ Alpizar-Rodr¨ªguez
%A Karen F¨¦rez-Blando
%A Luis Llorente
%J Clinical and Developmental Immunology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/618608
%X Previous studies showed that polymerized-type I collagen (polymerized collagen) exhibits potent immunoregulatory properties. This work evaluated the effect of intramuscular administration of polymerized collagen in early and established collagen-induced arthritis (CIA) in mice and analyzed changes in Th subsets following therapy. Incidence of CIA was of 100% in mice challenged with type II collagen. Clinimorphometric analysis showed a downregulation of inflammation after administration of all treatments (<0.05). Histological analysis showed that the CIA-mice group had extensive bone erosion, pannus and severe focal inflammatory infiltrates. In contrast, there was a remarkable reduction in the severity of arthritis in mice under polymerized collagen, methotrexate or methotrexate/polymerized collagen treatment. Polymerized Collagen but not methotrexate induced tissue joint regeneration. Polymerized Collagen and methotrexate/polymerized collagen but not methotrexate alone induces downregulation of CD4
%U http://www.hindawi.com/journals/cdi/2012/618608/