%0 Journal Article
%T Efecto del MVZ sobre la artritis inducida por adyuvante completo de Freund y ensayo de tolerancia Effect of MVZ on arthritis induced by complete Freund's adjuvant and tolerance assay
%A Yanier N迆ˋez Figueredo
%A Juana Till芍n Cap車
%A Yamilet Vega Hurtado
%A Carmen Carrillo Dom赤nguez
%J Revista Cubana de Plantas Medicinales
%D 2005
%I ECIMED
%X Se evalu車 el efecto antiartr赤tico inducido por administraci車n subplantar de adyuvante completo de Freund en ratas, de una soluci車n oleosa de jengibre (MVZ) . Los animales fueron sometidos a diferentes tratamientos y se les determin車 el porcentaje de inflamaci車n. Tambi谷n se realiz車 un ensayo de tolerancia para lo cual se emplearon ratones albinos sometidos a un ayuno de 4 h y posteriormente se administr車 por v赤a oral 1 mL/20 g de MVZ, se registraron los s赤ntomas t車xicos y se realiz車 el examen macrosc車pico de los 車rganos principales al final del estudio. El MVZ a las dosis ensayadas inhibi車 la inflamaci車n inducida, la dosis de 6,5 mL/kg de la sustancia de ensayo a los 30 d赤as posteriores a la administraci車n de adyuvante completo de Freund, present車 un efecto antiinflamatorio superior al mostrado por el tenoxicam a la dosis de 2,5 mg/kg. En el ensayo de tolerancia realizado, el MVZ no provoc車 signos de toxicidad, mortalidad, ni alteraciones macrosc車picas de los 車rganos principales. The antiarthritic effect of oily ginger solution (MVZ), induced by subplantar administration of Freund's complete adjuvant in rats, was evaluated. The animals were subjected to different treatments and the inflammation percentage was determined. A tolerance assay was also made with albinic mice that were put on a 4-hour fasting and later were administered 1 mL/20 g of MVZ by oral route. The toxic symptoms were registered and the macroscopic examination of the main organs was made at the end of the study. The MVZ at the assayed doses inhibited the induced inflammation. The dose of 6,5 mL/kg of the assay substance 30 days after the administration of the complete Freund's adjuvant presented an antiinflammatory effect higher than that showed by tenoxicam at doses of 2,5 mg/kg. In the tolerance assay carried out, the MVZ did not produce toxicity signs, mortality, or macroscopic alterations of the main organs.
%K MVZ
%K artritis
%K antiinflamatorio
%K ensayo de tolerancia
%K adyuvante completo de Freund.
%K MVZ
%K arthritis
%K inflammation
%K tolerance assay
%K complete Freund's adjuvant
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962005000100007