%0 Journal Article
%T 13-year mortality trends among hospitalized patients with inflammatory bowel disease
%A Justin L Sewell
%A Hal F Yee
%J BMC Gastroenterology
%D 2012
%I BioMed Central
%R 10.1186/1471-230x-12-79
%X We used the National Hospital Discharge Survey, a large nationally representative database, for the years 1994 through 2006. Age- and mortality-adjusted rates of in-hospital mortality and standardized mortality ratios were calculated for four time periods. Logistic regression analysis was used to assess associations between advancing time and mortality in adjusted analyses.150 (0.9%) of 17,393 hospitalizations for patients with inflammatory bowel disease ended in death. Age-adjusted in-hospital mortality decreased from 3.6 deaths per 1,000 hospital days in 1994¨C96 to 2.4 per 1,000 in 2003¨C06; standardized mortality ratio decreased from 0.33 to 0.27. Similar trends were seen for patients with ulcerative colitis, but mortality did not change over time among patients with Crohn¡¯s disease. Multivariable logistic regression analysis confirmed the significance of these changes in mortality, with 17% decreased odds of in-hospital death per three-year period (P£¿=£¿0.012). Subject age (OR 1.06 per year, P£¿<£¿0.001), Charlson comorbidity index (OR 1.29 per 1-point increase, P£¿<£¿0.001), and diagnosis of ulcerative colitis (versus Crohn¡¯s disease, OR 1.41, P£¿=£¿.042) were also associated with in-hospital mortality.The odds of in-hospital mortality among hospitalized patients with inflammatory bowel disease decreased by 17% per 3-year period from 1994 to 2006 in analysis adjusted for age and comorbidity status, in this large, nationally representative database. Multiple factors likely contribute to these trends.
%K Inflammatory bowel disease
%K Crohn¡¯s disease
%K Ulcerative colitis
%K Hospitalization
%K Epidemiology
%K Mortality
%K In-hospital mortality
%K Outcomes
%U http://www.biomedcentral.com/1471-230X/12/79/abstract