%0 Journal Article
%T Maculopat赤a por cloroquina Maculopathy from use of chloroquine
%A Odalys Gonz芍lez Peˋa
%A Eddy Mesa Hern芍ndez
%A Rafael Gonz芍lez D赤az
%A Caridad Monteagudo Morej車n
%J Revista Cubana de Oftalmologˋ-a
%D 2010
%I Editorial Ciencias M谷dicas
%X La toxicidad de la cloroquina est芍 relacionada con la dosis. Una dosis acumulativa de -100 g de cloroquina o una duraci車n del tratamiento de menos de 1 a o raramente se asocia con lesi車n retiniana. El riesgo de toxicidad aumenta significativamente cuando la dosis acumulativa excede los 300 g (250/d赤a por 3 a os). Se presenta un paciente del sexo femenino, con antecedentes de lupus eritematoso sist谷mico, hace 17 a os, para lo cual se le indic車 un tratamiento con cloroquina, (1 tableta 250 mg/diaria) durante 15 a os. Como s赤ntoma capital presentaba disminuci車n lenta y progresiva de la agudeza visual de 2 a os de evoluci車n; se le realiz車 un examen oftalmol車gico y otros ex芍menes complementarios que condujeron al diagn車stico de la enfermedad, y se estableci車 su tratamiento y su pron車stico. Se realizan recomendaciones. Chloroquine toxicity depends on the dose. A cumulative dose of under 100 g of chloroquine or a length of treatment for less than one year is rarely associated to any retinal lesion. The toxicity risk significantly increases with the cumulative dose over 300 g (250 g/day for three years). The case of a female patient with a history of lupus erythematosus for 17 years was presented. She was treated with chloroquine (one 250 mg every day) for 15 years. The main symptom was slow and progressive reduction of visual acuity experienced for 2 years; a complete ophthalmologic exam and other supplementary tests were indicated, which led to a diagnosis of maculopathy, and treatment and prognosis were then presented. Recommendations were made.
%K Maculopat赤a
%K cloroquina
%K Maculopathy
%K chloroquine
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21762010000200017