%0 Journal Article
%T Platelet-dependent thrombography gives a distinct pattern of in vitro thrombin generation after surgery with cardio-pulmonary bypass: potential implications
%A Said Rose
%A Regnault V¨¦ronique
%A Hacquard Marie
%A Carteaux Jean-Pierre
%J Thrombosis Journal
%D 2012
%I BioMed Central
%R 10.1186/1477-9560-10-15
%X Background Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB. Methods We used Calibrated Automated Thrombography to assess blood coagulation of 10 low-risk patients operated for valve replacement with CPB, under 2 experimental conditions, one implicating platelets as platelet dysfunction has been described to occur during CPB. Results Our main finding was that CPB-induced coagulopathy was differently appreciated depending on the presence or absence of platelets: the decrease in thrombin generation was much less pronounced in their presence (mean endogenous thrombin potential change values before and after CPB were -3.9% in the presence of platelets and -39.6% in their absence). Conclusion Our results show that experimental conditions have a profound effect in the study of in vitro thrombin generation in the context of CPB.
%K Cardio pulmonary bypass
%K Thrombin
%K Platelets
%K Thrombography
%U http://www.thrombosisjournal.com/content/10/1/15