%0 Journal Article
%T Olanzapine antagonizes the acquisition and expression of morphine-induced conditioned place preference in male and female mice
%A Parivash Hafez-Amini
%A Jamal Shams
%A Ali Shabahng-Saber-Tehrani
%A Ali Haeri-Rohani
%J Physiology and Pharmacology
%D 2006
%I Iranian Society for Physiology and Pharmacology
%X Introduction: Several investigations have indicated that dopamine D receptors could influence morphine 2 eward. The influence of olanzapine (a D dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (CPP) in male and female mice was investigated in the present study. Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in male and female -MRI mice (W: 20-25 g) were investigated in the present study. Resultd: Subcutaneous (s.c.) injection of morphine (1-10 mg/kg, three drug sessions) induced place preference oth in male and female mice. Intraperitoneal (i.p.) administration of olanzapine (0.5-5 mg/kg) induced place version (CPA) in female mice but not in male mice. Administration of olanzapine (1, 2.5, 5 mg/kg, i.p.) reduced oth the acquisition and expression of morphine-induced CPP in male and female mice. However, olanzapine (5 g/kg, i.p.) caused more than 80% mortality in female but not male mice. The effects of olanzapine were reversed y L-arginine (20 mg/kg, i.p.) pre-administration. Conlusion: We conclude that olanzapine reduced morphine effects via different mechanism/s.
%K Morphine
%K Olanzapine
%K Place preference
%K Nitric oxide
%K Mice.
%U http://www.phypha.ir/ppj/browse.php?a_code=A-10-74-3&slc_lang=en&sid=1