%0 Journal Article
%T STUDY OF INTERACTION OF DRUGS WITH BODY-ALIKE MACROMOLECULE (POLYVINYLPYRROLIDONE) BY ULTRA VIOLET SPECTROSCOPIC METHOD
%A AKHTAR SAEED
%A AMIN UR RAHMAN
%A NAZAR UL ISLAM
%A MOHAMMAD SAEED
%J Malaysian Journal of Pharmaceutical Sciences
%D 2006
%I 
%X UV-visible spectrophotometric technique was used to study the interaction of polyvinylpyrrolidone (PVP) with co-solutes: phenol, benzoic acid, sodium benzoate, salicylic acid and acetyl salicylic acid in aqueous medium. Changes in the absorption spectra of the co-solutes were observed in the presence of PVP from 200 to 210 nm. The changes were attributed to interaction of PVP molecules with the co-solute molecules. As the concentration of the co-solute increased, a red shift in the bands was observed indicating an increase in interaction between PVP and the co-solute.
%K Polyvinylpyrrolidone
%K Phenol
%K Benzoic acid
%K Acetyl salicylic acid
%K UV-visible spectrometry
%U http://www.usm.my/mjps/MJPS%204(2)%202006/MJPS%204.2.6.pdf