%0 Journal Article
%T Papel de la insulina en el tratamiento de la diabetes mellitus tipo II
%A Alberto Quirantes Hern芍ndez
%A Leonel L車pez Granja
%A Alipio Gil Sosa
%J Revista Cubana de Medicina General Integral
%D 1997
%I ECIMED
%X Se hace una revisi車n de las caracter赤sticas cl赤nicas, epidemiol車gicas y sociales de la diabetes mellitus tipo II (DMTII). Se analiza la fisiopatolog赤a de esta entidad y su manejo terap谷utico, y se exponen los mecanismos de acci車n de las sulfonilureas y la conducta que cl芍sicamente se ha seguido ante el fallo secundario a la acci車n de este medicamento y que ha consistido en sustituirlo, con la administraci車n insulina lenta en su lugar. En etapas m芍s recientes se plantea que en estos casos se mantiene la administraci車n de la sulfonilurea y se logra un adecuado control metab車lico al a adir una peque a dosis diaria de insulina lenta, lo que ofrece indudables ventajas para el paciente. Se propone un esquema terap谷utico sencillo con la asociaci車n de ambos medicamentos y se sugiere realizar nuevas investigaciones al respecto. The clinical, epidemiological and social characteristics of diabetes mellitus type II (DMTII) are reviewed. The physiopathology of this disease as well as its therapeutic management are analyzed. The mechanisms of action of sulphonylureas are also exposed. An explanation is given about the behavior that has been clasically followed when it is detected a secondary failure to the action of this drug, which is substituted, administrating slow insulin instead. It has been recently stated that in these cases when the administration of sulphonylurea is maintained, it is attained an adequate metabolic control by adding a small daily dosage of slow insulin, which is very advantageous for the patient. It is proposed a single therapeutic scheme with the association of both drugs, and it is suggested to male new investigations on this regards.
%K DIABETES MELLITUS NO INSULINO-DEPENDIENTE
%K DIABETES MELLITUS NO INSULINO-DEPENDIENTE
%K INSULINA
%K AGENTES HIPOGLICEMICOS
%K ALIBURIDA
%K QUIMIOTERAPIA COMBINADA
%K DIABETES MELLITUS
%K NON-INSULIN-DEPENDIENT
%K DIABETES MELLITUS
%K NON-INSULIN-DEPENDENT
%K INSULIN
%K HYPOGLYCEMIC AGENTS
%K ALYBURIDE
%K DRUG THERAPY
%K COMBINATION
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21251997000500012