%0 Journal Article
%T Attenuated Sensory Deprivation-induced Changes of Parvalbumin Neuron Density in the Barrel Cortex of Fc¦ÃRllB-deficient Mice
%A Watanabe
%A Makiko
%A Ueno
%A Hiroshi
%A Suemitsu
%A Shunsuke
%A Yokobayashi
%A Eriko
%J Acta Medica Okayama
%D 2012
%I Okayama University Medical School
%X Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of Fc¦ÃRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in Fc¦ÃRllB-deficient mice (Fc¦ÃRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between Fc¦ÃRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in Fc¦ÃRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that Fc¦ÃRllB contributes to sensory experience-regulated expression of PV.
%K parvalbumin
%K fast-spiking interneurons
%K Fc¦ÃRllB
%K barrel cortex
%K sensory deprivation
%U http://ousar.lib.okayama-u.ac.jp/file/48264/66_2_143.pdf.pdf