%0 Journal Article
%T Intraprostatic Botulinum Neurotoxin Type A Injection for Benign Prostatic Hyperplasia:Preliminary Results with a Newly Purified Neurotoxin
%A Yokoyama
%A Teruhiko
%A Yamamoto
%A Yumiko
%A Suzuki
%A Tomonori
%A Oguma
%A Keiji
%J Acta Medica Okayama
%D 2012
%I Okayama University Medical School
%X Several studies have demonstrated the efficacy of intraprostatic injection of botulinum neurotoxin type A (BoNT/A) against symptomatic benign prostatic hyperplasia (BPH). The most commonly used BoNT/A product, Botox , forms large complexes and composed of neurotoxin (NTX) as well as non-toxic components. We purified NTX lacking non-toxic components. We investigated the efficacy of this newly purified NTX for men with BPH. Ten male patients (mean age, 70.0 years) with BPH received 100 units (prostate volume [PV] £¼30ml) or 200 units (PV  30ml) of NTX injected into the prostate via a minimally invasive outpatient technique. Evaluation included uroflowmetry, postvoid residual urine volume (PVR), PV, and International Prostate Symptom Score (IPSS) measured at baseline and 1, 3, 6, and 12 months post-treatment. The status of 7 of the 10 patients examined was found to have improved within 1 month of treatment. The mean IPSS decreased from 23.8¡À7.0 to 16.3¡À10.3 (p£½0.0093) at 1 month, to 14.9¡À8.2 (p£½0.0074) at 3 months, and to 16.9¡À7.3 (p£½0.018) at 12 months. The mean PV decreased from 47.8¡À21.2 to 39.2¡À19.5ml (p£½0.0076) at 3 months. The PVR improved at 3 and 6 months post-treatment. Intraprostatic NTX injection induces prostate shrinkage and is effective in men with BPH.
%K botulinum neurotoxin type A
%K benign prostatic hyperplasia
%K therapy
%U http://ousar.lib.okayama-u.ac.jp/file/48668/66_4_291.pdf