%0 Journal Article
%T THE ROLE OF THE HYPOTHALAMUS LESIONS IN WOMEN'S STERILITY - AN EXPERIMENTAL STUDY
%A Vuka Kati£¿
%A Stevo Najman
%A Jelena £¿ivanov-Curlis
%A Vladmila Bojanic
%J Acta Medica Medianae
%D 2001
%I The Faculty of Medicine in Nis
%X The anovulatory cycles and amenorrhea in the female patients with Cushing'ssyndrome, coupled with sterility, the Cushingoid type of obesity in our experiment as well as contradictory data about sterility of rats and mice in the identical experimentrepresent the reasons for studyng the function and morphology of the ovaries in theanimals treated by monosodium glutamate (MSG).The experimental group of the black mice C57BL/6.T of the female gender hasbeen treated by an intraperitoneal solution of MSG in the dose of 4,4 mg/g of the bodyweightfrom the first to the ninth day after birth. The coupling of the treated femaleswith the untreated males was done after 90 days of age; these females were sacrificed120 days after birth. The ovaries were removed and fixed in the solution of 10%fonnaldehyde, manually treated and cut on the microtone. The paraffin sections werecolored by HE, PAS and Van Giesen methods. The identical procedure was alsoappliced to the control group of animals of both sexes.All the treated animals were sterile. The ovaries were enlarged, cystic, withoutyellow or albinic bodies. In the control females, there were Graf follicles found invarious phases of maturation as well as luteinized stroma.The paper discusses the disturbance of the hypothalamus-hypophysis-gonadaxis caused by the damage of the hypothalamus regions secreting various "releasing"hormones.
%K Hypothalamus obesity
%K monosodium glutamate
%K cystic ovaries
%U http://publisher.medfak.ni.ac.rs/2001-html/1-broj-2001/ULOGA%20HIPOTALAMUSNIH%20LEZIJA%20U%20STERILITETU%20ZENA.pdf