%0 Journal Article
%T Efecto antifibr車tico del interefr車n alfa 2b recombinante en la cirrosis hep芍tica por virus B o C Antifibrotic effect of recombinant interferon alfa 2b in liver cirrhosis caused by virus B or C
%A Enrique Ar迆s Soler
%A Nelson A. P谷rez Brioso
%A Mar赤a Parrilla Delgado
%A Carlos Dom赤nguez 芍lvarez
%J Revista Cubana de Medicina
%D 2005
%I ECIMED
%X Se evalu車 el efecto antifibr車tico del interfer車n alfa 2b recombinante utilizado durante un a o (6 millones de U 3 veces a la semana) en pacientes con cirrosis hep芍tica por virus B o C mediante estudios histol車gicos y de ecograf赤a Doppler antes de concluido el tratamiento y despu谷s. Se valor車 el perfil bioqu赤mico hep芍tico durante ese a o. Participaron en la investigaci車n 10 pacientes. Se encontr車 en el an芍lisis global del m谷todo morfom谷trico aplicado al estudio histol車gico y en la ecograf赤a Doppler que no hubo disminuci車n estad赤sticamente significativa de la fibrosis hep芍tica, pero individualmente disminuy車 en 3 de los enfermos tratados y se detuvo en uno. El m谷todo de evaluaci車n semicuantitativo de la fibrosis en la biopsia hep芍tica no mostr車 que se revirtiera el proceso fibr車tico. Se detect車 una mejor赤a estad赤sticamente significativa en las aminotranferasas. Se detectaron efectos adversos que coinciden con lo reportado en la literatura nacional e internacional revisada The antifibrotic effect of recombinant interferon alfa 2b used for a year (6 millions of U 3 times a week) in patients with liver cirrhosis caused by virus B or C was evaluated by histological studies and Doppler echography before and after concluding the treatment. The hepatic biochemical profile was assessed during that year. 10 patients participated in the research. In the global analysis of the morphometric method applied to the histological study and in the Doppler echography, it was found that there was no statistically significant reduction of liver fibrosis, but it individually decreased in 3of the patients treated and it stopped in one. The semiquantitative method for evaluating fibrosis in the liver biopsy did not show a reversion of the fibrotic process. A statistically marked improvement was observed in the aminotransferases. Adverse effects coinciding with what is reported in the national and international literature reviewed were detected.
%K Cirrosis hep芍tica
%K tratamiento
%K interfer車n
%K acci車n antifibr車tica
%K Liver cirrhosis
%K treatment
%K interferon
%K antifibrotic action
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232005000400008