%0 Journal Article
%T La amiloidosis como complicaci車n de la anemia drepanoc赤tica Amyloidosis as a complication of drepanocytic anemia
%A Adalberto Fort迆n Prieto
%A Carlos Alberto Le車n Gonz芍lez
%A Mirta Caridad Campo D赤az
%A Alfredo Pileta Matos
%J Revista Cubana de Medicina
%D 2005
%I ECIMED
%X Se realiz車 un estudio ambipectivo, anal赤tico y longitudinal en 15 pacientes con anemia drepanoc赤tica durante el per赤odo comprendido entre 1995 y el 2001 con el objetivo de evaluar la existencia de amiloidosis sist谷mica, mediante la realizaci車n de biopsia de la grasa abdominal, se utilizaron las t谷cnicas de Cristal Violeta y Rojo Congo; se consider車 como diagn車stico los resultados positivos en ambas coloraciones, lo que sucedi車 en 6 pacientes (40 %). Se revisaron las microhistorias de seguimiento para determinar el comportamiento cl赤nico-hematol車gico de la enfermedad, se utilizaron como variables las cifras promedio de hemoglobina y reticulocitos, los niveles de hemoglobina fetal y la frecuencia de crisis vasoclusivas, de transfusiones as赤 como de episodios infecciosos. Se evalu車 la relaci車n entre estas variables y la existencia de amiloidosis mediante el c芍lculo del riesgo relativo, no se encontr車 relaci車n estad赤sticamente significativa en ning迆n caso; aunque pudo demostrarse un aumento del riesgo de amiloidosis relacionado con la frecuencia de infecciones y las crisis vasoclusivas. An ambiopective, analytical and longitudinal study was conducted in 15 patients with drepanocytic anemia between 1995 and 2001 aimed at evaluating the existance of systemic amyloidosis by performing biopsy of the abdominal fat. The Violet Glass and and Congo Red techniques were used. The positive results in both stainings, which were observed in 6 patients (40 %), were considered as a diagnosis. The microhistories of follow-up were reviewed to determine the clinical and hematological behavior of the disease. The average figures of hemoglobin and reticulocytes, the levels of fetal hemoglobin and the frequency of vasoocclusive crises, of transfusions, as well as of infectious episodes, were used as variables. The relation between these variables and the existance of amyloidosis was evaluated by calculating the relative risk. No statistical significant relation was found in any case, although an increase of the risk for amyloidosis related to the frequency of infections and to the vasoocclusive crises could be proved.
%K Anemia drepanoc赤tica
%K amiloidosis
%K Drepanocytic anemia
%K amyloidosis
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232005000200003