%0 Journal Article
%T Clonidina oral en la medicaci¨®n prean¨¦stesica del paciente hipertenso
%A Julia Flores Gonz¨¢lez
%A Rolando Mart¨ªnez Garc¨ªa
%A Soledad Herrera Estupi£¿¨¢n
%A Hilev Larrondo Muguercia
%J Revista Cubana de Investigaciones Biom£¿£¿dicas
%D 1996
%I ECIMED
%X Se dise a un estudio para evaluar la eficacia y seguridad de la clonidina como medicaci¨®n preanest¨¦sica del paciente hipertenso. Se trataron 50 sujetos hospitalizados para cirug¨ªa mayor electiva entre 20 y 65 a os de edad, ambos sexos, cifras tensionales en 140/90 o m¨¢s, clase II de riesgo de la ASA, asign¨¢ndose aleatoriamente al tratamiento con clonidina o placebo v¨ªa oral en un ensayo prospectivo y a doble ciegas. Se administr¨® una dosis de 0,075 mg de clonidina 8, 12 y 16 horas antes del proceder quir¨²rgico. No hubo diferencias estad¨ªsticamente significativas entre ambos grupos respecto a la edad, sexo, valores de tensi¨®n sist¨®lica, diast¨®lica, media o pulso radial iniciales. Se evaluaron dichos par¨¢metros cada 6 horas en el pre y posoperatorio. La clonidina disminuy¨® las cifras tensionales en ambos per¨ªodos. Se presentaron reacciones adversas sin importancia cl¨ªnica en el 27 % de los casos. La somnolencia fue el efecto secundario m¨¢s com¨²n. No se detectaron casos de hipotensi¨®n ortost¨¢tica. El alfa agonista redujo la frecuencia de reacciones hipertensivas en el per¨ªodo posoperatorio (34 %) comparativamente con el placebo (58 %). A study is designed to assess the efficacy and safety of clonidine as preanesthetic medication for the hypertensive patient. Fifty inpatients going through elective major surgery were treated; they had between 20 and 65 years old, both sexes, tension figures in 140/90 or more, class II of ASA risk, and they were randomly assigned to clonidine treatment or oral placebo in a prospective double blind assay. A dose of 0,075 mg clonidine was administered 8, 12 and 16 hours before the surgical procedure. There were no statistically significant differences between both groups with respect to age, sex, values of systolic tension, diastolic, initial mean or radial pulse. Such parameters were assessed every 6 hours at pre and postoperatory. Clonidine decreased the tension figures in both periods. Adverse reactions without clinical importance occurred in the 27 % of the cases. Drowsiness was the most common secondary effect. No orthostatic hypotension cases were detected. The alpha-agonist reduced the frequency of hypertensive reactions in the postoperatory period (34 %) compared with the placebo (58 %).
%K MEDICACION PREANESTESICA
%K CLONIDINA
%K CLONIDINA
%K HIPERTENSION
%K INTRODUCCION
%K PREANESTHETIC MEDICATION
%K CLONIDINE
%K CLONIDINE
%K HYPERTENSION
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03001996000100004