%0 Journal Article
%T Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice
%A Tang Xin-Hui
%A Chen Jin
%A Yang Xiao-Lan
%A Yan Li-Fang
%J Pharmacognosy Magazine
%D 2010
%I Medknow Publications
%X Mechanisms underlying the mitochondrial protection of Limonium sinense extracts (LSE) was studied in lipopolysaccharide and D-galactosamine (LPS/D-GalN) intoxicated mice. It was found that increased activities of serum aspartate aminotransferase and alanine aminotransferase induced by LPS/D-GalN were significantly inhibited by pretreatment with LSE. The obvious disruption of membrane potential, intramitochondrial Ca 2+ overload and suppression in mitochondrial Ca 2+ -ATPase activity induced by LPS/D-GalN were significantly blocked by pretreatment with LSE. It was concluded that mechanisms underlying protection of LSE against liver mitochondria damage might be related to the preservation on mitochondrial Ca 2+ homeostasis through the preservation on mitochondrial Ca 2+ -ATPase activity.
%K D-galactosamine
%K Limonium sinense (Girard) Ktze
%K lipopolysaccharide
%K mitochondrial Ca 2+ -ATPase activity
%K mitochondrial Ca 2+ overload
%U http://www.phcog.com/article.asp?issn=0973-1296;year=2010;volume=6;issue=23;spage=191;epage=197;aulast=Tang